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Fig. 3 | Cancer Cell International

Fig. 3

From: Single-cell RNA sequencing reveals cellular and molecular heterogeneity in extensive-stage small cell lung cancer with different chemotherapy responses

Fig. 3

Characterization of epithelial cells and malignant cells between PD group and PR group. A UMAP projection of subclustered epithelial cells from 9 treatment-naive ES-SCLC samples. Each dot corresponds to a single cell, colored by cell type and group. B Heatmap of marker gene expression in epithelial cell subtypes. C Heatmap of large-scale CNVs in epithelial cells using immune cells as references. D Heatmap of genes in malignant cells differentially expressed between PD_TU group and PR_TU group. E, F GO and KEGG pathway enrichment of genes in malignant cells differentially expressed between PD_TU group and PR_TU group. G Violin plots with dots showing differential expression of genes associated with ribosome between PD_TU group and PR_TU group. Each dot corresponds to a single cell. H Number of cellular interactions with malignant cells in two groups. I, J Ligand-receptor bubble diagram of malignant cells acting on different cells in PD_TU group and PR_TU group

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Cancer Cell International

ISSN: 1475-2867

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