Table 3 MicroRNA-regulated autophagy in cervical cancer cells
From: To be or not to be: navigating the influence of MicroRNAs on cervical cancer cell death
MicroRNA (Expression) | Target | Samples | Function in cervical cell autophagy | Note | Ref |
|---|---|---|---|---|---|
miR-197 | RNF113A | Human (Cervical squamous cell carcinoma tissues), In vitro (CESC cells) | Promotes | MiR-197 inhibits proliferation and enhances autophagy of cervical squamous cell carcinoma by targeting RNF113A. | [159] |
miR-155-5p | PDK1 | In vitro (C33A, Siha and HeLa cells) | Promotes | MiR-155-5p aggravates CC cells autophagy by targeting PDK1. | [153] |
miR-20a | THBS2 | In vitro (SiHa and HeLa cells) | Promotes | Silencing miR-20a leads to the autophagy suppression in CC cells by targeting THBS2. | [130] |
miR-21 | PTEN | In vitro (SiHa cells) | Inhibits | MiR-21 inhibits the autophagy and apoptosis of CC cells by targeting PTEN. | [235] |
miR-21 | PTEN | In vitro (SiHa and HeLa cells) | Inhibits | Upregulated miR-21 mediate with HIF-1α aggravates radio-resistance in CC cells by inhibiting autophagy through targeting PTEN. | [303] |
miR-19-3p (Up) | PTEN | Human (CC tissues), In vitro (SiHa and HeLa cells) | Inhibits | MiR-19-3p inhibits autophagy and apoptosis of CC cells by targeting PTEN. | [236] |
miR-9-5p (Up) | SOCS5 | Human (CC tissues), In vitro (SiHa cells) | Inhibits | MiR-9-5p alleviates CC autophagy by decreasing autophagosome through targeting SOCS5. | [304] |
miR-204 | ATF2 | In vitro (C33A cells) | Inhibits | MiR-204 inhibits autophagy and incudes apoptosis of CC cells by targeting ATF2. | [160] |
miR-338 (Down) | ATF2 | Human (CC tissues), In vitro (SiHa and HeLa cells) | Inhibits | MiR-338 alleviates CC cells autophagy by activating mTOR pathway through negatively regulating ATF2. | [161] |
miR-30a | - | In vitro (HeLa cells) | Inhibits | MiR-30a decreases the autophagy of CC cells induced with Hydroxycamptothecin (HCPT). | [305] |
miR-34-5p | ATG4B | In vitro (SiHa and HeLa cells) | Inhibits | MiR-34-5p induces sensitivity of CC cells to pirarubicin by suppressing pirarubicin-induced autophagy through targeting ATG4B. | [175] |
miR-875-5p | MDM4 | In vitro (CC cells) | Inhibits | Silencing miR-875-5p leads to induction of the CC cells autophagy by targeting MDM4. | [306] |
miR-224-3p | FIP200 | In vitro (HPV-16+SiHa, and HPV-18+Hela) | Inhibits | MiR-224-3p suppresses CC cells autophagy by negatively regulating FIP200. | [307] |
miR‑378 | ATG12 | In vitro (HPV-16+SiHa, and HPV-18+Hela) | Inhibits | MiR‑378 inhibits the autophagy of CC cells by targeting ATG12. | [176] |
miR-106a | LKB1 | In virto (HPV-positive SiHa and HeLa cells) | Inhibits | MiR-106a alleviates the CC cells autophagy by targeting LKB1. | [308] |