Fig. 1

Overview of study design. Baseline tissue biopsies and plasma ctDNA from 34 MCL patients receiving first-line chemotherapy were analyzed using targeted next-generation sequencing to characterize the mutational landscape and assess the concordance of somatic genomic variant detection between paired samples. Pretreatment ctDNA was further investigated to evaluate its association with treatment response and prognosis. Longitudinal plasma samples from representative patients highlighted the importance of interim ctDNA monitoring for disease surveillance