Table 2 Morphological characteristics of Swi/Snf-deficient ECAs
Parameters | Total (n = 604) | Swi/Snf-intact (n = 568) | Swi/Snf-deficient (n = 36) | P |
|---|---|---|---|---|
Medullary, n (%) | < 0.001 | |||
Absent | 574(95.0) | 555(97.7) | 19(52.8) | |
Present | 30(5.0) | 13(2.3) | 17(47.2) | |
Signet ring cell (≥ 5%), n (%) | 1 | |||
Absent | 587(97.2) | 552(97.2) | 35(97.2) | |
Present | 17(2.8) | 16(2.8) | 1(2.8) | |
Micropapillary (≥ 10%), n (%) | 0.861 | |||
Absent | 562(93.0) | 507(89.3) | 33(91.7) | |
Present | 42(7.0) | 61(10.7) | 3(8.3) | |
Tumor heterogeneity, n (%) | < 0.001 | |||
Absent | 480(79.5) | 461(81.2) | 19(52.8) | |
Present | 124(20.5) | 107(18.8) | 17(47.2) | |
Differentiation, n (%) | 0.004 | |||
Well | 34(5.6) | 33(5.8) | 1(2.8) | |
Moderate | 331(54.8) | 320(56.3) | 11(30.5) | |
Poor | 239(39.6) | 215(37.9) | 24(66.7) | |
Nuclear grade, n (%) | 0.001 | |||
1 | 51(8.4) | 51(9.0) | 0(0) | |
2 | 352(58.3) | 338(59.5) | 14(38.9) | |
3 | 201(33.3) | 179(31.5) | 22(61.1) | |
Mitosis (/10HPF) | 0.217 | |||
Median (range) | 20.00(0-240) | 21.00(0-240) | 16.00(0–90) | |
Necrosis, n (%) | 0.001 | |||
Absent | 417(69.0) | 401(70.6) | 16(44.4) | |
Present | 187(31.0) | 167(29.4) | 20(55.6) | |
Host inflammatory response | ||||
sTILs, (%) | < 0.001 | |||
Median(range) | 15.00(1–90) | 10(1–90) | 60.00(1–90) | |
Peritumoral lymphocytes, n (%) | 0.001 | |||
Absent | 367(60.8) | 358(63.0) | 9(25.0) | |
Present | 237(39.2) | 210(37.0) | 27(75.0) | |
TLS, n (%) | < 0.001 | |||
Absent | 515(85.3) | 494(87.0) | 21(58.3) | |
Present | 89(14.7) | 74(13.0) | 15(41.7) | |
Neutrophilic infiltration, n (%) | 0.052 | |||
Absent | 519(85.9) | 492(86.6) | 27(75) | |
Present | 85(14.1) | 76(13.4) | 9(25) |