Table 2 The tumor-suppressive effects of MSC-Exos
From: Progress of mesenchymal stem cell-derived exosomes in targeted delivery of antitumor drugs
Source of exosomes | Tumor type | Mechanism affecting tumors | Effect on tumor progression | Reference |
|---|---|---|---|---|
Human Bone marrow | Breast cancer | Induces dormancy by repressing the target gene MARCKS. | Promoting breast cancer cell dormancy in metastatic ecological niches | [47] |
Human Bone marrow | Leukemia | MSC-Exos-carried miR-222-3p regulates the IRF2/INPP4B pathway | miR-222-3p inhibits leukemia cell proliferation and promotes apoptosis | [49] |
Human Bone marrow | Pancreatic cancer | Inhibition of the Wnt8/β-catenin signaling pathway | Inhibition of invasion, migration, proliferation and stemness of pancreatic cancer cells | [49] |
Human umbilical cord | Endometrial cancer | Inhibited the AKT signaling pathway | Inhibition of cell cycle protein D1 expression in endometrial cancer cells | [46] |
Human Umbilical Cord Wharton’s Jelly | Bladder cancer | down-regulated phosphorylation of Akt protein kinase and up-regulated cleaved Caspase 3 | Induction of apoptosis in bladder tumor cells in vitro and in vivo | [47] |
MenSC and umbilical cord | Oral squamous cell carcinoma | not quite clear | Inhibition of angiogenesis and tumor growth | [51] |