Progress of mesenchymal stem cell-derived exosomes in targeted delivery of antitumor drugs

Table 5 MSC-Exos delivers novel anti-tumor drugs

Drug	Source of exosomes	In vivo model	Tumor type	Loading method	Therapeutic effect	Reference
miR-145-5p	Human Umbilical cord	PDAC mice	Pancreatic	Transfection	Increased tumor cell apoptosis and significantly inhibited tumor growth	[110]
miR-381	Bone marrow	None	Breast cancer	Electroporation	migratory and invasive capacity and promotes apoptosis	[111]
miR-499	Bone marrow	BALB/c nude mice	Endometrial cancer	Electroporation	Significantly inhibited endometrial cancer cell proliferation, endothelial cell tube formation, and inhibited tumor growth and angiogenesis	[112]
LNA anti-miR-142-3p	Bone marrow	SCID mice	Breast cancer	Electroporation	Reduced tumorigenicity of breast cancer stem cells in vivo	[113]
miR-124	Bone marrow	BALB/c nude mice	Pancreatic	Transfection	Inhibited cell proliferation, metastasis and epithelial mesenchymal transition and enhanced chemosensitivity to 5-fluorouracil in vitro and in vivo	[114]
Tumor Necrosis Factor α	Bone marrow	BALB/c nude mice	Melanoma	Electroporation	Good targeting properties, better anti-tumor activity and lower toxicity	[115]

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