Table 1 YEATS2 in major cancer types and targeted pathways/genes

NSCLC

MYC, RPS6, RPL7

ATAC complex recruitment, H3K9ac deposition

Drives ribosomal gene addiction; essential for growth

[27]

PDAC

BCL2, XIAP, PD-L1

TAK1/NF-κB stabilization, PD-L1 regulation; HIF1α-TWIST1/EMT axis

Promotes survival, Chemoresistance, immune evasion; Mediates hypoxia-induced metastasis

[32, 33, 39]

HCC

AKT1, MYC, CCND1

PI3K-AKT activation, AKT stabilization; p53/p21

Enhances metabolic reprogramming and therapy resistance; independent prognostic marker

[28, 35, 49]