Table 3 Research roadmap for YEATS2
From: YEATS2: a novel cancer epigenetic reader and potential therapeutic target
Focus Area | Key Goals | Tools/Methods |
|---|---|---|
Structural Biology | Resolve YEATS2 complexes with acylated histones | Cryo-EM, X-ray crystallography |
Chemical Probes | Develop isoform-selective inhibitors/degraders | PROTACs, photoaffinity labeling |
Functional Genomics | Map YEATS2 dependencies in tumor subtypes | CRISPR-Cas9 screens, spatial transcriptomics |
Translational Studies | Validate YEATS2 as a biomarker/therapeutic target | Patient-Derived Xenograft (PDX) models, clinical cohort analyses |