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Fig. 8 | Cancer Cell International

Fig. 8

From: Fibrogenesis-driven tumor progression in clear cell renal cell carcinoma: prognostic, therapeutic implications and the dual role of neuropilin-1

Fig. 8

Effects of NRP1 knockdown on ccRCC cell proliferation and apoptosis. A, B IHC analysis of ccRCC patient samples showing significantly higher NRP1 expression in tumor tissues. C NRP1 expression across different tumor grades in ccRCC. D NRP1 expression across various ccRCC cell lines, with selection of high-expression models 786-O and Caki-1. E Validation of siRNA knockdown efficiency, identifying siNRP1-3 as the optimal sequence. F CCK-8 assay results showing reduced cell viability post-NRP1 knockdown. G EdU staining indicating decreased cell proliferation. H Flow cytometry results showing G1 phase arrest. I Apoptosis analysis revealing increased apoptotic rates in siNRP1 cells. J Western blot analysis of apoptosis-related proteins

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Cancer Cell International

ISSN: 1475-2867

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