Table 1 The patient characteristics of the two clear cell renal cell carcinoma clusters
Characteristics | Cluster C1 (n = 147) | Cluster C2 (n = 383) | P-value |
|---|---|---|---|
Age, median (IQR) | 62 (53, 69) | 61 (52, 70) | 0.847 |
Gender, n (%) | 0.018 | ||
Male | 107 (20.2%) | 237 (44.7%) | |
Female | 40 (7.5%) | 146 (27.5%) | |
Histologic grade, n (%) | |||
G1 | 0 (0%) | 14 (2.7%) | |
G2 | 44 (8.4%) | 184 (35.2%) | |
G3 | 57 (10.9%) | 149 (28.5%) | |
G4 | 44 (8.4%) | 30 (5.7%) | |
Histologic grade (integrated), n (%) | < 0.001 | ||
G1 + G2 | 44 (8.4%) | 198 (37.9%) | |
G3 + G4 | 101 (19.3%) | 179 (34.2%) | |
Pathologic stage, n (%) | |||
Stage I | 49 (9.3%) | 217 (41.2%) | |
Stage II | 18 (3.4%) | 39 (7.4%) | |
Stage III | 46 (8.7%) | 77 (14.6%) | |
Stage IV | 32 (6.1%) | 49 (9.3%) | |
Pathologic stage (integrated), n (%) | < 0.001 | ||
Stage I + Stage II | 67 (12.7%) | 256 (48.6%) | |
Stage III + Stage IV | 78 (14.8%) | 126 (23.9%) | |
T stage, n (%) | |||
T1 | 51 (9.6%) | 221 (41.7%) | |
T2 | 20 (3.8%) | 49 (9.2%) | |
T3 | 68 (12.8%) | 111 (20.9%) | |
T4 | 8 (1.5%) | 2 (0.4%) | |
T stage (integrated), n (%) | < 0.001 | ||
T1 + T2 | 71 (13.4%) | 270 (50.9%) | |
T3 + T4 | 76 (14.3%) | 113 (21.3%) | |
N stage, n (%) | < 0.001 | ||
N0 | 66 (25.9%) | 174 (68.2%) | |
N1 | 12 (4.7%) | 3 (1.2%) | |
M stage, n (%) | 0.033 | ||
M0 | 114 (22.8%) | 308 (61.7%) | |
M1 | 30 (6%) | 47 (9.4%) | |
OS event, n (%) | < 0.001 | ||
Alive | 80 (15.1%) | 277 (52.3%) | |
Dead | 67 (12.6%) | 106 (20%) | |