Fig. 1
From: SP1 promotes triple-negative breast cancer progression by targeting USP5
USP5 is highly expressed in TNBC and is associated with poor prognosis in TNBC patients. (A) Expression of USP5 is higher in TNBC than in normal breast tissues in TCGA data. ***P < 0.001. (B) USP5 expression was detected using an immunohistochemical technique in TNBC carcinoma and para-carcinoma tissues. (C) USP5 protein expression in carcinoma tissues (n = 172) was significantly higher than that in para-carcinoma tissues (n = 130). r = 0.331, P < 0.001. Scale bars, 100 μm. (D) Representative IHC images of USP5 in TNBC carcinoma tissues. Scale bars, 100 μm. (E) The expression of USP5 correlates positively with the TNM stage in human TNBC samples. r = 0.472, P < 0.001. (F) High expression of USP5 is correlated with poor overall survival of TNBC patients. Log-rank P = 0.0047. (G, H) The USP5 mRNA (G) and protein (H) expression in normal breast epithelial cells (MCF-10 A) and TNBC cells (MDA-MB-231 and SUM-159). **P < 0.01, *P < 0.05