Fig. 5
From: SP1 promotes triple-negative breast cancer progression by targeting USP5
SP1 is highly expressed and positively correlated with USP5 expression in TNBC. (A) SP1 expression was detected using an immunohistochemical technique in TNBC carcinoma and para-carcinoma tissues. (B) SP1 protein expression in carcinoma tissues (n = 172) was significantly higher than that in para-carcinoma tissues (n = 130). r = 0.362, P < 0.001. Scale bars, 100 μm. (C) Representative IHC images of SP1 in TNBC carcinoma tissues. Scale bars, 100 μm. (D) The expression of SP1 correlates positively with the TNM stage in human TNBC samples. r = 0.316, P < 0.001. (E) High expression of SP1 is correlated with poor overall survival of TNBC patients. Log-rank P = 0.019. (F) The expression of SP1 and USP5 are positively correlated in TNBC samples. r = 0.405, P < 0.001. (G) Kaplan–Meier curves show that the overall survival of patients with high SP1 and USP5 expression in TNBC tumors was shorter than that of those with low SP1 and USP5 expression. Log-rank P = 0.0027