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Fig. 1 | Cancer Cell International

Fig. 1

From: The regulation of LRPs by miRNAs in cancer: influencing cancer characteristics and responses to treatment

Fig. 1

The miRNA/LRPSs axis in Colorectal cancer. (A) Under various stress conditions, LRP1, p53, and miR-103/107 constitute a feedback regulatory loop, modulating the apoptosis of colorectal cancer cells. Oncogenic lncRNAs and circRNAs repress miR-103/107, thereby enhancing LRP1 expression. (B) LRP6, miR-92, and DKK3 form a positive feedback loop in colorectal cancer, synergistically with oncogenic lncRNAs, to promote LRP6 expression. This enhancement facilitates increased invasion, metastasis, and chemoresistance

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Cancer Cell International

ISSN: 1475-2867

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