Table 1 The regulatory roles of MiRNA in various human malignancies

Colorectal cancer

miR-103

LRP1, p53, HIF-1.

[29–30]

miR-107

LRP1, PRE3/4.

[31,32,33]

miR-92a

LRP6, DKK3.

[49]

miR-15

LRP6, RUNX2.

[55]

miR-487b

LRP6, MYC, SYZ12, KRAS.

[58]

Pancreatic cancer

miR-429

LRP1, TBK1, FOXD1, ERK.

[63–64, 66–67]

miR-26b

LRP6, CDK14

[73]

miR-194

LRP6

[74]

miR-15a-5p

BHLHE40

[81]

miR-577

LRP6, PI3K/AKT, LIN28B, COL1A1

[82,83,84]

miR-454

LRP6

[89]

Hepatocellular cancer

miR-455-5p

IGF-1R, AKT, GLUT1, PD-L1, LRP4

[95,96,97]

miR-1269a

LRP6

[105]

miR-202

HK2, BCL2, LRP6

[106,107,108]

miR-432

WNT/β-catenin signaling, LRP6.

[109]

miR-610

-catenin, LRP6,

[110]

miRNA-126-3p

LRP6, WNT/β-catenin signaling

[114]

miR-26a/b-5p

LRP6, WNT/β-catenin signaling

[116]

miR-338

LRP6

[118]

Gastric cancer

miR-140-5p

LRP4, WNT/β-catenin signaling, YES1, NDRG3

[6, 119, 121]

miR-545-3p

EMS1, LRP5

[125, 126]

miR-142

LRP8, ERK

[20]

Esophageal Cancer

miR-590

LRP6, WNT/β-catenin signaling

[136]

breast cancer

miR-424

CDK1, CDC42, LRP6

[146,147,148]

miR-130a-3p

SATB1, RAB5B, AKT/mTOR signaling, LRP6

[151,152,153]

miR-1262

WNT/β-catenin signaling, MAPK, LRP8

[16, 154–155]

Prostate cancer

miR-301b-3p

LRP1B

[164]

miR-500

LRP1B

[166]

miR-455-5p

Caspase-3, CCR5, LRP8

[167–168]

Thyroid carcinoma

miR-196a-5p

LRP1B, PPP2R1B

[172, 174]

miR-548a-5p

MMP-2, LRP1B

[173]

miR-199a-5p

SNAI1, PD-L1, Claudin-1

[176–177]

miR-429,

XIAP, LRP4

[181–182]

miR-146b-5p

LRP6, ZNRF3, CCDC6, WNT/β-catenin signaling

[183,184,185]

miR-1271

IRS, AKT, LRP6, WNT/β-catenin signaling

[186–187]

Reproductive system cancers

miR-346

LRP6

[188]

miR-362-3p

MMP-2, MMP-9, integrins α5, integrins β1 SERBP1

[189,190,191]

Melanoma

miR-103/107

DAPK, KLF4, Axin2, AKT, PTEN Cav-1, POU3F2, β-catenin, LRP1

[36, 37, 199,200,201,202,203]

miR-199a-3p/5p, miR-1908

APOE3, LRP1

[204]

Glioblastoma

miR-124

ELF4, LRP1

[211]

miRNA-205

VEGF-A, AKT/mTOR signaling, LRP1

[212,213,214,215,216]

miR-513c

LRP6, PLK4, TCF7

[220,221,222]

miR-137

LRP6, EZH2, Cox-2, CXCL12, SP1, CSE1L, PTP4A3, XIAP

[218, 224,225,226,227,228, 230, 233]

miR-577

LRP6, WNT/β-catenin signaling

[236]

miR-128, miR-150, miR-577, miR-126

RAS/MAPK signaling, LRP6, WNT/β-catenin signaling

[115, 236,237,238,239,240,241,242]

Lung cancer

miR-375

LRP5

[246]

miR-30b-5p

LRP8

[250]

Dermatofibrosarcoma protuberans

miR-205

LRP1, ERK

[251]

Neuroendocrine tumor

miR-196a

LRP4, LRP5, LRP6

[255]