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Fig. 1 | Cancer Cell International

Fig. 1

From: FBXL18 promotes endometrial carcinoma progression via destabilizing DUSP16 and thus activating JNK signaling pathway

Fig. 1

FBXL18 was highly expressed in EC tissues and cells, and augmented expression predicted poor prognosis. (A) The expression of FBXL18 in various tumors from the TIMER database. (B) The mRNA expression pattern of FBXL18 in EC tissues and corresponding normal tissues was analyzed using the UALCAN database. (C) The comparison of FBXL18 mRNA level in normal tissues and EC tissues of different tumor stage. (D-E) Western blot analysis of FBXL18 protein levels in twelve pairs of EC tissues and adjacent normal tissues, and quantitative analysis. (F) qRT-PCR analysis of FBXL18 mRNA levels in twelve paired EC tissues and adjacent normal tissues. (G) qRT-PCR analyses of FBXL18 mRNA levels in normal endometrial stromal cells (ESC) and a variety of EC cells (KLE, Ishikawa, HEC-1B, RL95-2). (H) The association of FBXL18 expression and patients’ overall survival was determined. *P < 0.05; **P < 0.01; ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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