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Fig. 2 | Cancer Cell International

Fig. 2

From: FBXL18 promotes endometrial carcinoma progression via destabilizing DUSP16 and thus activating JNK signaling pathway

Fig. 2

Silence of FBXL18 impeded cell proliferation, migration, and invasion, and suppressed EMT in EC cells. (A) The mRNA levels of FBXL18 in EC cells of shNC and shFBXL18 groups were detected by qRT-PCR. (B-C) Western blot analysis of FBXL18 protein levels in EC cells of shNC and shFBXL18 groups, and quantitative analysis. (D-G) CCK-8 and colony formation assays were conducted to assess cell proliferation abilities in stably infected EC cells, and quantitative analyses. (H-I) Transwell invasion assay was used to evaluate invasiveness in EC cells after silencing FBXL18, and quantitative analysis. (J-L) Wound healing assay was employed to determine cell migration ability after silencing FBXL18 in KLE and Ishikawa cells, and quantitative analysis. (M-O) Western blot analysis of EMT related markers (N-cadherin, Vimentin, and E-cadherin) in EC cells of shNC and shFBXL18 groups, and quantitative analysis. *P < 0.05; **P < 0.01; ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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