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Fig. 3 | Cancer Cell International

Fig. 3

From: FBXL18 promotes endometrial carcinoma progression via destabilizing DUSP16 and thus activating JNK signaling pathway

Fig. 3

Enforced expression of FBXL18 accelerated cell proliferation, migration, and invasion, and promoted EMT in EC cells. (A) The mRNA levels of FBXL18 in EC cells of LV-Control and LV-FBXL18 groups were detected by qRT-PCR. (B-C) Western blot analysis of FBXL18 protein levels in EC cells of LV-Control and LV-FBXL18 groups, and quantitative analysis. (D-G) CCK-8 and colony formation assays were conducted to assess cell proliferation abilities in stably infected EC cells, and quantitative analyses. (H-I) Transwell invasion assay was used to evaluate invasiveness in EC cells after overexpressing FBXL18, and quantitative analysis. (J-L) Wound healing assay was employed to determine cell migration ability after FBXL18 overexpression in KLE and Ishikawa cells, and quantitative analysis. (M-O) Western blot analysis of EMT related markers (N-cadherin, Vimentin, and E-cadherin) in EC cells of LV-Control and LV-FBXL18 groups, and quantitative analysis. *P < 0.05; **P < 0.01; ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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